Ouabain as a mammalian hormone.

  title={Ouabain as a mammalian hormone.},
  author={W. Schoner and Natali B Bauer and Jochen M{\"u}ller-Ehmsen and U. Kr{\"a}mer and Njde Hambarchian and Robert H. G. Schwinger and Hans M{\"o}ller and Holger Kost and Christine Weitkamp and Thomas Schweitzer and Ulrike Kirch and Horst Neu and E G Gr{\"u}nbaum},
  journal={Annals of the New York Academy of Sciences},
Endogenous ouabain changes rapidly in humans and dogs upon physical exercise and is under the control of epinephrine and angiotensin II. Hence, the steroid acts as a rapidly acting hormone. A search for a specific binding globulin for cardiac glycosides in bovine plasma resulted in the identification of the d allotype of the micro chain of IgM whose hydrophobic surfaces interact with cardiotonic steroids and cholesterol. Such IgM complexes might be involved in the hepatic elimination of… CONTINUE READING


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