Otx2 regulates subtype specification and neurogenesis in the midbrain.

  title={Otx2 regulates subtype specification and neurogenesis in the midbrain.},
  author={Bertrand Vernay and Muriel Koch and Flora M Vaccarino and James Briscoe and Antonio Simeone and Ryoichiro Kageyama and S Ang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 19},
The transcription factor Otx2 is required to determine mesencephalic versus metencephalic (cerebellum/pons) territory during embryogenesis. This function of Otx2 primarily involves positioning and maintaining the mid-hindbrain organizer at the border between midbrain and anterior hindbrain. Otx2 expression is maintained long after this organizer is established. We therefore generated conditional mutants of Otx2 using the Cre/loxP system to study later roles during rostral brain development. For… CONTINUE READING