Otx2 expression in anterior neuroectoderm and forebrain/midbrain is directed by more than six enhancers.

@article{Kurokawa2014Otx2EI,
  title={Otx2 expression in anterior neuroectoderm and forebrain/midbrain is directed by more than six enhancers.},
  author={Daisuke Kurokawa and Tomomi Ohmura and Yusuke Sakurai and Kenichi Inoue and Yoko Suda and Shinichi Aizawa},
  journal={Developmental biology},
  year={2014},
  volume={387 2},
  pages={203-13}
}
Otx2 plays essential roles in each site at each step of head development. We previously identified the AN1 enhancer at 91kb 5' upstream for the Otx2 expressions in anterior neuroectoderm (AN) at neural plate stage before E8.5, and the FM1 enhancer at 75kb 5' upstream and the FM2 enhancer at 122kb 3' downstream for the expression in forebrain/midbrain (FM) at brain vesicle stage after E8.5. The present study identified a second AN enhancer (AN2) at 88kb 5' upstream; the AN2 enhancer also… CONTINUE READING

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