Otx2 Gene Deletion in Adult Mouse Retina Induces Rapid RPE Dystrophy and Slow Photoreceptor Degeneration

@inproceedings{Bby2010Otx2GD,
  title={Otx2 Gene Deletion in Adult Mouse Retina Induces Rapid RPE Dystrophy and Slow Photoreceptor Degeneration},
  author={Francis B{\'e}by and Michael Housset and Nicolas Fossat and Coralie Le Greneur and Fr{\'e}d{\'e}ric Flamant and Pierre Godement and Thomas Lamonerie},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Many developmental genes are still active in specific tissues after development is completed. This is the case for the homeobox gene Otx2, an essential actor of forebrain and head development. In adult mouse, Otx2 is strongly expressed in the retina. Mutations of this gene in humans have been linked to severe ocular malformation and retinal diseases. It is, therefore, important to explore its post-developmental functions. In the mature retina, Otx2 is expressed in three cell types… CONTINUE READING

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