Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen.

@article{Raffel2009Ott1I,
  title={Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen.},
  author={Glen D. Raffel and Gerald C. Chu and Jonathan L. Jesneck and Dana E. Cullen and Roderick Terry Bronson and Olivier Adrien Bernard and Dwight Gary Gilliland},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 2},
  pages={333-41}
}
The infant leukemia-associated gene Ott1 (Rbm15) has broad regulatory effects within murine hematopoiesis. However, germ line Ott1 deletion results in fetal demise prior to embryonic day 10.5, indicating additional developmental requirements for Ott1. The spen gene family, to which Ott1 belongs, has a transcriptional activation/repression domain and RNA recognition motifs and has a significant role in the development of the head and thorax in Drosophila melanogaster. Early Ott1-deficient… CONTINUE READING