Ototoxicity of topical otomicrobial agents.

  title={Ototoxicity of topical otomicrobial agents.},
  author={Dr. Clifford W. Barlow and Larry G. Duckert and C S Kreig and George A. Gates},
  journal={Acta oto-laryngologica},
  volume={115 2},
Topical antimicrobial solutions are used commonly for prevention or treatment of purulent otorrhea even though most solutions contain ototoxic agents. This study compares the cochlear and middle ear toxicity of cortisporin otic solution (COS), 0.3% gentamicin ophthalmic solution (GOS), benzalkonium chloride (0.026% and 0.05%), and 1.0% Ofloxacin, a new quinolone antibiotic. Saline 0.9% was used as a control. The agent was instilled daily for 7 days into the bulla of juvenile guinea pigs. The… CONTINUE READING


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