Ototoxicity of neomycin and its penetration through the round window membrane into the perilymph.

@article{Harada1986OtotoxicityON,
  title={Ototoxicity of neomycin and its penetration through the round window membrane into the perilymph.},
  author={Teruhiko Harada and Masao Iwamori and Yoshitaka Nagai and Yasuya Nomura},
  journal={The Annals of otology, rhinology, and laryngology},
  year={1986},
  volume={95 4 Pt 1},
  pages={404-8}
}
The ototoxicity of neomycin and its concentration in the perilymph after direct application on the round window membrane were studied. After placing 5 mg of neomycin on the round window membrane of guinea pigs for various time intervals, concentration of the drug in the perilymph was determined by high performance liquid chromatography, and the cochlea was examined by light microscopy. Neomycin penetrated the round window membrane quite easily, and its concentration in the perilymph became… CONTINUE READING

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