Ototoxicity of kanamycin in albino and pigmented guinea pigs. I. A morphologic and electrophysiologic study.


Ototoxic drugs of the aminoglycoside type have been shown to accumulate to melanin, suggesting a possible mechanism for their ototoxicity. The present study was undertaken by combining electrophysiologic and morphologic methods to investigate whether the ototoxicity of kanamycin is different in pigmented and albino guinea pigs. In pigmented animals a… (More)


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