Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig.

@article{Fleischman1975OtotoxicityOC,
  title={Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig.},
  author={R. Fleischman and S. Stadnicki and M. F. Ethier and U. Schaeppi},
  journal={Toxicology and applied pharmacology},
  year={1975},
  volume={33 2},
  pages={
          320-32
        }
}
cis-Dichlorodiammine platinum (II) (NSC-119 875), an agent with potent antineoplastic activity which also induces renal, intestinal, and bone marrow toxicity, was tested for ototoxic effects in guinea pigs. Ototoxicity was evaluated by the disappearance of Preyer's reflex in response to pure tones of 5, 7, and 10 kHz and by histopathological evaluation of the inner ear with surface preparations or midmodiolar sections. Groups of five guinea pigs treated with 8–40 ip injections of cis… Expand
Ototoxicity of cis-dichlorodiammine platinum (II) in guinea pigs.
TLDR
There was a close correlation between loss of the cochlear hair cells and suppression of thecochlear microphonics in guinea pigs treated with cis-dichlorodiammine platinum (II). Expand
Ototoxic and Nephrotoxic Effects of Combined Treatment with cis-Diamminedichloroplatinum and Kanamycin in the Guinea Pig
TLDR
Combined treatment with CSP and kanamycin produced the most significant cortical medullary tubular necrosis and interstitial nephritis and for the first time localization of platinum in the inner ear is reported. Expand
Effects of α-tocopherol on cisplatin-induced ototoxicity in guinea pigs
TLDR
Results strongly suggest that α-tocopherol suppresses CDDP-induced ototoxicity and nephrotoxicity via the suppression of the increased production of reactive oxygen species. Expand
Pathophysiology of the Ototoxicity of Cis-Diamminedichloroplatinum
  • S. Komune, S. Asakuma, J. Snow
  • Medicine
  • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 1981
TLDR
The electrophysiologic and histopathologic changes in the inner ear caused by the administration of cis-diamminedichloroplatinum (CP) were studied in guinea pigs and it was demonstrated that the outer hair cells are destroyed in the basal turn of the cochlea and are preserved in the upper turns, while the innerhair cells are almost completely preserved in all turns. Expand
Effects of trolox, locally applied on round windows, on cisplatin-induced ototoxicity in guinea pigs.
TLDR
It is suggested that a local application of trolox in the tympanic cavity can be a promising candidate to prevent the CDDP-ototoxicity in the future. Expand
Cisplatin-induced ototoxicity: Morphological evidence of spontaneous outer hair cell recovery in albino guinea pigs?
TLDR
It is suggested that OHCs recover from cisplatin-induced damage 1-4 weeks after treatment, however, the results do not allow a conclusion as to whether the observed recovery is due to the formation of new O HCs or to (self-)repair of damaged OHC's. Expand
[Protective effect of fosfomycin on cisplatin-induced ototoxicity in rats].
TLDR
Comparison of different dosage schedules with a total dose of 10mg/kg of cisplatin showed that the higher daily dose for a shorter time period produced more marked loss of the outer hair cells, and the mechanism of reduction in ototoxicity may be considered as a result of reduction of renal damage. Expand
Cis-Diamminedichloroplatinum (II) Ototoxicity in the Guinea Pig
TLDR
OHC degeneration was most pronounced in the basal turns of the cochlea with greatest severity in the inner row and Alteration of supporting cell ultrastructure preceded detectable change in OHC. Expand
Cisplatin-induced ototoxicity: Audiometric findings and experimental cochlear pathology
SummaryTwenty-four (48%) out of a group of 50 patients treated with one to three single doses of cisplatin compound (cis-DDP), at a dosage of 60 mg/ m2 body surface, were found to have deteriorationExpand
d-Methionine provides excellent protection from cisplatin ototoxicity in the rat
TLDR
D-methionine (D-Met), a sulfur containing compound, was tested as an otoprotectant in male Wistar rats and provided excellent o toprotection even at the lowest level with complete o Toprotection obtained for the 300 mg/kg dosing as measured by both ABR and SEM. Expand
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TLDR
Renal lesions were the most severe toxic changes in survivors and were manifested by azotemia, hypochloremia, proteinuria, appearance of urinary erythrocytes, leukocytes and decreased 24-hr excretion of lactate dehydrogenase in dogs and by protracted polyuria in monkeys. Expand
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Generally, it seemed to be possible that higher metabolic activities of the outer hair cells are responsible for weakness of the cells in pathologic processes in the ear. Expand
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It was suggested that if the persistent inhibitory action on DNA synthesis is directly related to the chemotherapeutic efficacy of this agent or a metabolic product thereof, a less frequent treatment regimen may be as effective as daily injections while evoking fewer toxic reactions. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Viewing the short duration of the blood level of antibiotics consider more frequent injections of every six hours necessary to the maintenance of therapeutically effective blood concentrations, and this suggestion should be considered critically. Expand
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