Ototoxicity from Combined Cisplatin and Radiation Treatment: An In Vitro Study

  title={Ototoxicity from Combined Cisplatin and Radiation Treatment: An In
Vitro Study},
  author={Wong Kein Low and Sylvia W. W. Kong and Michelle Guet Khim Tan},
  booktitle={International journal of otolaryngology},
Objective. Combined cisplatin (CDDP) and radiotherapy is increasingly being used to treat advanced head and neck cancers. As both CDDP and radiation can cause hearing loss, it is important to have a better understanding of the cellular and molecular ototoxic mechanisms involved in combined therapy. Procedure. The effects of CDDP, radiation, and combined CDDP-radiation on the OC-k3 cochlear cell line were studied using MTS assay, flow cytometry, Western blotting, and microarray analysis. Results… CONTINUE READING

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