Ototoxicity due to cis-diamminedichloroplatinum in the treatment of ovarian cancer: influence of dosage and schedule of administration.

@article{Waters1991OtotoxicityDT,
  title={Ototoxicity due to cis-diamminedichloroplatinum in the treatment of ovarian cancer: influence of dosage and schedule of administration.},
  author={Gloria Waters and Mukhtar Ahmad and Athanasios Katsarkas and Gerald W Stanimir and John McKay},
  journal={Ear and hearing},
  year={1991},
  volume={12 2},
  pages={91-102}
}
Ototoxicity associated with administration of cisplatin was assessed in four groups of patients suffering from advanced ovarian carcinoma. The purpose was to determine the influence of dosage, schedule of administration, and long-term treatment on pure-tone thresholds and other auditory parameters. One hundred and forty-five serial audiograms were obtained in 60 patients and compared with baseline audiograms. The treatment protocol consisted of two different dosages (low--50 mg/m2 and high--100… CONTINUE READING

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