Ototoxic Effects of Occupational Exposure to Styrene and Co-Exposure to Styrene and Noise

@article{liwiskaKowalska2003OtotoxicEO,
  title={Ototoxic Effects of Occupational Exposure to Styrene and Co-Exposure to Styrene and Noise},
  author={M. Śliwińska-Kowalska and E. Zamyslowska-Szmytke and W. Szymczak and P. Kotyło and M. Fiszer and W. Wesołowski and M. Pawlaczyk-łuszczyńska},
  journal={Journal of Occupational and Environmental Medicine},
  year={2003},
  volume={45},
  pages={15-24}
}
Learning ObjectivesRecall the reported effects of exposure to styrene and noise on the cochlear hair cells and hearing function in rats.Describe which possible confounding factors were and were not controlled for in this study, and what the results indicate about the respective ototoxic effects on humans of exposure to styrene and noise.Characterize the effects in humans of isolated and combined exposure to styrene and noise. Ototoxicity of styrene and the synergistic action of styrene and… Expand
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TLDR
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TLDR
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TLDR
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Relationship between styrene exposure and hearing loss: review of human studies.
  • Ann-Christin Johnson
  • Medicine
  • International journal of occupational medicine and environmental health
  • 2007
TLDR
Seven studies show some effects on the auditory system that were associated with styrene-alone exposure, and these effects are examined using different outcome measures such as pure tone audiometry, high frequency hearing loss, and central hearing tests. Expand
Hazards to hearing from combined exposure to toluene and noise in rats.
TLDR
In combined exposure to low-levels of noise and toluene, even a long-term exposure did not reveal a potential hazard of hearing impairment, andSynergistic interaction was demonstrated in short-term Exposure to 1500 ppm toLUene and both to WBN and impulse noise, but hearing impairment was much larger when following exposure to impulse noise. Expand
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The results suggest that the two ototoxicants, noise and styrene, can cause a permanent synergistic loss of auditory sensitivity. Expand
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Age and noise exposures were highly important variables, both positively associated with hearing loss, and the detrimental effect of noise exposure on hearing acuity was found to be strengthened with increased age. Expand
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Hearing and outer hair cell losses were larger after the exposure to both ethanol and styrene than those induced by styrene alone, indicating a clear potentiation of styrene ototoxicity by ethanol. Expand
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Results indicate that CSF and IEF were free from detectable solvents, whereas the organ of Corti, the nerves, and the brain were contaminated, and both toluene- and styrene-induced hearing losses are caused by tissue intoxication rather than by fluid contamination. Expand
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