Otosclerosis 1: the aetiopathogenesis of otosclerosis

@article{Uppal2009Otosclerosis1T,
  title={Otosclerosis 1: the aetiopathogenesis of otosclerosis},
  author={Sandeep Uppal and Yogesh Bajaj and I K Rustom and Andrew P. Coatesworth},
  journal={International Journal of Clinical Practice},
  year={2009},
  volume={63}
}
Otosclerosis is a bone dystrophy localised to the inner ear and the stapes footplate. Otosclerosis is a frequent cause of deafness in adults. The patient with otosclerosis typically presents with a history of slowly progressive conductive or mixed hearing loss that is usually bilateral and often asymmetric, usually between the ages of 15 and 45 years. The disease is characterised by alternating phases of bone resorption and formation. The majority of studies on families with otosclerosis… Expand
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TLDR
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TLDR
Although audiometric and imaging examinations and VEMP testing can confirm the preoperative diagnosis, the histolopathologic examination of the removed stapes footplate is the most accurate way to determine the diagnosis of otosclerosis. Expand
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The surgical management for otosclerosis has evolved from stapes mobilisation to total extraction of the footplate, the so called ‘stapedectomy’, to a small hole in the stapes footplate, theExpand
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Perspectives of pharmacological treatment in otosclerosis
TLDR
In conclusion, stapes surgery remains to be widely accepted treatment of conductive hearing loss due to otosclerosis, and the place of pharmacological treatment targeting inflammation and bone metabolism needs to be determined by future studies. Expand
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TLDR
Given that the majority of participants in this study exhibited mixed hearing loss preoperatively, the results suggest that stapedotomy can also be effective in improving thresholds for these patients, andStapedotomy is a safe and effective treatment option for patients with otosclerosis. Expand
Are computed tomography and densitometric measurements useful in otosclerosis with mixed hearing loss? A retrospective clinical study
TLDR
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