Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.

  title={Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.},
  author={Inna Hughes and Brian Blasiole and David Huss and Mark E. Warchol and Nigam P Rath and Bel{\'e}n Hurl{\'e} and Elena Ignatova and J. David Dickman and Ruediger Thalmann and Robert Levenson and David M Ornitz},
  journal={Developmental biology},
  volume={276 2},
Orientation with respect to gravity is essential for the survival of complex organisms. The gravity receptor is one of the phylogenetically oldest sensory systems, and special adaptations that enhance sensitivity to gravity are highly conserved. The fish inner ear contains three large extracellular biomineral particles, otoliths, which have evolved to transduce the force of gravity into neuronal signals. Mammalian ears contain thousands of small particles called otoconia that serve a similar… CONTINUE READING


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