Otologic effects of topical mitomycin C: phase I-evaluation of ototoxicity.

HYPOTHESIS To determine ototoxicity of topical mitomycin C when placed in the middle ear at varying concentrations. BACKGROUND Despite meticulous surgical technique and diligent postoperative care, some patients develop excessive scar and granulation tissue in the middle ear or mastoid cavity. Poor wound healing may result in infection, tympanic membrane… CONTINUE READING