Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion

@inproceedings{Johnson2010OtoferlinIA,
  title={Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion},
  author={Colin P Johnson and Edwin R Chapman},
  booktitle={The Journal of cell biology},
  year={2010}
}
Otoferlin is a large multi-C2 domain protein proposed to act as a calcium sensor that regulates synaptic vesicle exocytosis in cochlear hair cells. Although mutations in otoferlin have been associated with deafness, its contribution to neurotransmitter release is unresolved. Using recombinant proteins, we demonstrate that five of the six C2 domains of otoferlin sense calcium with apparent dissociation constants that ranged from 13-25 µM; in the presence of membranes, these apparent affinities… CONTINUE READING

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