Otoconia degeneration as a consequence of primary hyperparathyroidism.

  title={Otoconia degeneration as a consequence of primary hyperparathyroidism.},
  author={Kelly A McKenna and Khalil ur Rahman and Kourosh Parham},
  journal={Medical hypotheses},
2 Citations

Advances in otolith-related protein research

The proteins that play important roles in otolith formation and maintenance are provided, providing new insight for the prevention and management of benign paroxysmal positional vertigo (BPPV) and basis for otolith-related proteins as potential biomarkers of vestibular disease.




Primary hyperparathyroidism as the result of chronic kidney disease is important in the genesis of renal bone disease, and several new treatments could help achieve the guidelines set out by the kidney disease outcomes quality initiative.

Classical complications of primary hyperparathyroidism.

Impaired Calcium Metabolism in Benign Paroxysmal Positional Vertigo: A Topical Review.

This topical review explores the evidence related to the association between deficient calcium metabolism and BPPV and describes the development of therapeutic options to prevent recurrences and introduces results from a recent randomized controlled trial on the effect of vitamin D and calcium supplementation.

Delayed diagnosis of juvenile primary hyperparathyroidism.

The case of a young female whom the authors suspect had PHP from the age of 6 years, which remained undiagnosed for the next 11 years in spite of repeated hospital admissions, illustrates two important advances in parathyroid hormone measurement with a new sensitive immuno-radiometric assay and in the development of radionuclide scanning for localization ofParathyroid adenoma(s).

Primary Hyperparathyroidism in Pediatric Patients

The diagnosis of primary hyperparathyroidism in pediatric patients is frequently delayed, is commonly symptomatic, and has significant morbidity, and evaluation of serum calcium and PTH levels is diagnostic in 100% of children.

Primary hyperparathyroidism in children and adolescents

Presentation of the patients with primary hyperparathyroidism is similar to their adult counterparts except for more severe bone disease and less severe renal disease.

Benign Paroxysmal Positional Vertigo in Older Women May be Related to Osteoporosis and Osteopenia

Osteopenia or osteoporosis was found in 24 of the 32 patients (75%) with BPPV, and the T-scores were compared in 3 age groups to those of 83 healthy women, who had a significantly lower T-score.

Primary hyperparathyroidism in a paediatric hospital.

PHPT is rare in children but usually associated with end-organ damage, presumably due to delayed diagnosis, and should be considered in the differential diagnosis of unexplained non-specific complaints.

Decreased serum vitamin D in idiopathic benign paroxysmal positional vertigo

It is demonstrated that vitamin D insufficiency and deficiency were associated with BPPV with the odds ratios of 3.88–77.0 (95 % confidence interval = 6.51–9.38) and 23.4 ± 8.1 %, p < 0.001).

Calcium Oxalate Stone Formation in the Inner Ear as a Result of an Slc26a4 Mutation*♦

It is shown for the first time that calcium oxalate stones are formed in the mouse inner ear of a genetic model for hearing loss and vestibular dysfunction in humans, and a novel mechanism for the accumulation and aggregation of oxalates in the inner ear is proposed.