Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells

@article{Ganda1996OtiloniumAP,
  title={Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells},
  author={L. Gand{\'i}a and M. Villarroya and B. Lara and V. Olmos and J. Gilabert and M. L{\'o}pez and R. Mart{\'i}nez-Sierra and R. Borges and A. Garc{\'i}a},
  journal={British Journal of Pharmacology},
  year={1996},
  volume={117}
}
1 Otilonium, a clinically useful spasmolytic, behaves as a potent blocker of neuronal nicotinic acetylcholine receptors (AChR) as well as a mild wide‐spectrum Ca2+ channel blocker in bovine adrenal chromaffin cells. 2 45Ca2+ uptake into chromaffin cells stimulated with high K+ (70 mM, 1 min) was blocked by otilonium with an IC50 of 7.6 μm. The drug inhibited the 45Ca2+ uptake stimulated by the nicotinic AChR agonist, dimethylphenylpiperazinium (DMPP) with a 79 fold higher potency (IC50 = 0.096… Expand
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