Other Neuroprotective Therapies on Trial in Acute Stroke

@article{Ferro2006OtherNT,
  title={Other Neuroprotective Therapies on Trial in Acute Stroke},
  author={Jos{\'e} M. Ferro and Antoni D{\'a}valos},
  journal={Cerebrovascular Diseases},
  year={2006},
  volume={21},
  pages={127 - 130}
}
New neuroprotective agents on trial may potentially offer benefit to stroke patients without the associated hemorrhagic risk of thrombolytic therapy. Clinical investigation of these drugs has been designed to obtain the highest probability of success, or concentrates on the salvageable ischemic brain and use infarct growth on MRI as a surrogate end-point. Nine substances in 10 trials are currently being tested in three therapeutical strategies in patients with acute ischemic stroke. These… 

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References

SHOWING 1-10 OF 21 REFERENCES

Major ongoing stroke trials.

  • Medicine
    Stroke
  • 2007
Treatment with oral anticoagulants in the current INR range is safe, and potential mechanisms of action include lowering blood pressure, improving cerebral perfu-sion, and neuroprotection, according to preclinical and preliminary clinical data.

Oral Citicoline in Acute Ischemic Stroke: An Individual Patient Data Pooling Analysis of Clinical Trials

Treatment with oral citicoline within the first 24 hours after onset in patients with moderate to severe stroke increases the probability of complete recovery at 3 months, and the overall safety ofciticoline was similar to placebo.

Recommendations for standards regarding preclinical neuroprotective and restorative drug development.

The suggestions contained in this document are meant to serve as overall guidelines that must be adapted to the individual characteristics related to particular drugs and their preclinical and clinical development needs.

NXY-059 for acute ischemic stroke.

The administration of NXY-059 within six hours after the onset of acute ischemic stroke significantly improved the primary outcome (reduced disability at 90 days), but it did not significantly improve other outcome measures, including neurologic functioning as measured by the NIHSS score.

Recommendations for Clinical Trial Evaluation of Acute Stroke Therapies

The recommendations contained in this document may help to focus attention on how to achieve the goal of developing an expanding number of a effective and safe acute stroke therapies.

Major ongoing stroke trials.

The following is a list of major ongoing studies about stroke. Information about other multicenter studies that might be included in this list should be submitted to the Stroke Editorial Office by

The BRAINS Study: Safety, Tolerability, and Dose-finding of Repinotan in Acute Stroke

  • P. TealF. SilverD. Simard
  • Medicine
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 2005
The incidence of adverse events was comparable with all doses of repinotan and placebo, and no safety issues were observed, and a trend toward better tolerability with evidence of efficacy was observed with the rep inotan 1.25 mg/d dose.

Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia: the Glucose Insulin in Stroke Trial (GIST).

GKI infusions can be safely administered to acute stroke patients with mild to moderate hyperglycemia producing a physiological but attenuated glucose response to acute strokes, the effectiveness of which remains to be elucidated.

Recommendations for the Management of Intracranial Haemorrhage – Part I: Spontaneous Intracerebral Haemorrhage

These recommendations are endorsed by the 3 European societies which are represented in the EUSI: the European Stroke Council, the European Neurological Society and the European Federation of Neurological Societies.