Other Antiandrogens

  title={Other Antiandrogens},
  author={J. Schmidt},
  pages={153 - 157}
Various substances of steroidal or nonsteroidal structure may serve as an alternative for the antiandrogenic treatment of acne. Compounds with antiandrogenic properties like cimetidine or ketoconazole are rarely administered for acne due to their weak effects. In contrast, spironolactone is an effective antiandrogen that shows good treatment effects in hirsutism and acne. Side effects occur frequently and are dose dependent. Isotretinoin – the most effective agent in acne therapy – has been… Expand
Hormonelle Antiandrogene in der Aknetherapie
F females with acne tarda, persistent acne recalcitrant to treatment, with parallel wish of contraception, and as a requirement for a systemic isotretinoin treatment can be treated with hormonal antiandrogen treatment, but this is not a primary monotherapy for uncomplicated acne. Expand
Update and Future of Systemic Acne Treatment
Hormonal treatment represents an alternative regimen in female acne, whereas it is mandatory in resistant, severe pubertal or post-adolescent forms of the disease and, especially, new anti-inflammatory agents, such as lipoxygenase inhibitors. Expand
Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review
Evidence of limited quality to underpin the expert endorsement of spironolactone at the doses typically used (≤100 mg/day) in everyday clinical practice is identified. Expand
Responsiveness of Dupuytren’s disease fibroblasts to 5α-dihydrotestosterone
The palmar fascia is a target tissue for androgen action via androgen receptors and further studies are required to determine whether control of androgen receptor may control the evolution of Dupuytren's disease. Expand
The role of androgen and androgen receptor in skin-related disorders
Recent studies of androgen/AR roles in several skin-related disorders, including acne vulgaris, androgenetic alopecia and hirsutism, as well as cutaneous wound healing are reviewed. Expand
The investigation of the frequency of menstrual irregularity and hypertrichosis due to isotretinoine usage in female patients
Female acne patients who were started isotretinoin treatment and who had no history of menstrual irregularities and hypertrichosis within 6 months prior to isot retinoin use and had no any systemic disease and did not take any medicine except isotretinosin were included in the study. Expand
The Acute Anticonvulsant Effects of Deoxycorticosterone in Developing Rats: Role of Metabolites and Mineralocorticoid‐receptor Responses
The mechanisms that mediate the acute anticonvulsant effects of deoxycorticosterone (DOC) were investigated in young rats in a bid to understand the mechanism of action of this steroid. Expand


Treatment of hirsutism with the pure antiandrogen flutamide.
Treatment with the antiandrogen flutamide and an oral contraceptive resulted in a particularly rapid and marked decrease in the total hirsutism score, which reached the normal range at 7 months. Expand
Isotretinoin treatment alters steroid metabolism in women with acne
Although pretreatment levels of urinary steroid metabolites were not abnormal, the ratios of the 5α/5β metabolites were at the upper limit of the reference range and were lowered after treatment, suggesting that 5α‐reductase activity is sensitive to isotretinoin. Expand
The effect of ketoconazole on sebum secretion in patients suffering from acne and seborrhoea.
A statistically significant decrease in the rate of sebum production in all patients administered with a single daily oral dose of ketoconazole is found, suggesting that the drug could be proposed as a useful alternative in the treatment of acne and seborrhoea. Expand
Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients.
Data clearly showed that skin androgen receptor was sensitive to oral isotretinoin administration in acneic patients, consistent with the absence of sebum in complete androgen-insensitive patients and normal sebum production in male pseudohermaphrodites. Expand
Androgens and Therapeutic Aspects of Antiandrogens in Women
Antiandrogens provide a logical and clinically effective pharmacotherapy of hyperandrogenic disorders and both steriodal and nonsteroidal antiandrogens may cause significant side effects, largely because of their interactions not only with androgen receptors, but also with other receptors and various enzymatic activities. Expand
Cimetidine is an antiandrogen in the rat.
Cimetidine is a nonsteroidal-antiandrogen and this property may contribute to the production of gynecomastia in cimetidine-treated men, which is linked to the development of breast enlargement in men. Expand
Ketoconazole binds to the human androgen receptor.
  • C. Eil
  • Biology, Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 1992
Ketoconazole appears to be the first example of a non-steroidal compound which binds competitively to both SSBG and multiple steroid hormone receptors, suggesting that the ligand binding sites of these proteins share some features in common. Expand
Ketoconazole therapy: hormonal and clinical effects in non-tumoral hyperandrogenism.
After 9 months of ketoconazole treatment, the patients' Ferriman & Gallway scores improved markedly and acne had improved markedly, and Hormone patterns also became more favorable, with decreases in androgenic steroids and increases in estradiol. Expand
Effects of topically applied spironolactone on androgen stimulated sebaceous glands in the hamster pinna.
The effects of spironolactone (5% SYC-201G, a preparation developed for clinical use in acne vulgaris by Searle Yakuhin K.K.), which is known to have antiandrogenic effects by competitivelyExpand
Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial.
The present data obtained in a randomized prospective study clearly demonstrate that the pure antiandrogen flutamide is superior to spironolactone in the treatment of female hirsutism and its related androgen-dependent symptoms and signs in women. Expand