Ostracising caffeine from the pharmacological arsenal for attention-deficit hyperactivity disorder – was this a correct decision? A literature review

  title={Ostracising caffeine from the pharmacological arsenal for attention-deficit hyperactivity disorder – was this a correct decision? A literature review},
  author={Konstantinos Ioannidis and Samuel R. Chamberlain and Ulrich M{\"u}ller},
  journal={Journal of Psychopharmacology},
  pages={830 - 836}
Caffeine is one of the most widespread psychotropic substances in the world. It exerts multiple effects on the brain including adenosine receptor antagonism, and thereby has been found to modulate aspects of cognition, including attention, in animal models and in healthy human volunteers. This review considers what is known of the effects of caffeine on symptoms and cognitive functions in attention-deficit hyperactivity disorder (ADHD), a prototypical disorder of cognitive dysfunction. We… 
Effects of Caffeine Consumption on Attention Deficit Hyperactivity Disorder (ADHD) Treatment: A Systematic Review of Animal Studies
The hypothesis that the cognitive effects of caffeine found in animal models could be translated to human ADHD, particularly during adolescence, is strengthened, and the role of caffeine in modulating ADHD-like symptoms of hyperactivity and impulsivity is contradictory, raising discrepancies that require further clarification.
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Differential Behavioral and Biochemical Responses to Caffeine in Male and Female Rats from a Validated Model of Attention Deficit and Hyperactivity Disorder
The data revealed that caffeine intake since childhood attenuated behavioral alterations in the ADHD model associated with changes in BDNF and TrkB receptors in the hippocampus, and provided insight into the potential of caffeine against fully cognitive impairment displayed by females inThe ADHD model.
Exploring the Role of Caffeine Use in Adult-ADHD Symptom Severity of US Army Soldiers
The use of caffeinated compounds appears to be increased among military soldiers with ADHD, and they may help reducing A-ADHD symptoms and improve cognitive performance, suggesting a possible role for caffeine as a potential pharmacological tool in the treatment of adult ADHD.
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Impact of ADHD symptoms on clinical and cognitive aspects of problem gambling.
Purinergic system in psychiatric diseases
A comprehensive search of the literature about the role and function of the purinergic system in the development and predisposition to psychiatric disorders, with a focus on depression, schizophrenia, bipolar disorder, autism, anxiety and attention deficit/hyperactivity disorder is performed.
Adenosine A2A receptor antagonists: from caffeine to selective non‐xanthines
The A2A receptor has become a prototypical example of utilizing high‐resolution structures of GPCRs for the rational design of chemically diverse drug molecules and it is understood this interaction at the atomic level.


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This review article aims to address the specific research studies and case reports that relate caffeine to psychiatric symptoms by recognizing, educating, and treating patients using a tapering approach.
Caffeine abuse: the phantom differential in sleep complaints/disorders?
The postulate that caffeine consumption may be an aetiology in many sleep-related complaints, and it is suggested that when evaluating the history of substance abuse in a patient in the outpatient clinic, theHistory of caffeine consumption should be included in the psychiatric evaluation.
Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies.
The present data suggest that caffeine and selective adenosine A2A receptor antagonists can improve memory performance in rodents evaluated through different tasks and afford protection against memory dysfunction elicited in experimental models of aging, Alzheimer's disease, Parkinson's disease and, in spontaneously hypertensive rats (SHR), a putative genetic model of attention deficit hyperactivity disorder (ADHD).
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Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline.
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A selective spatial learning deficit in SHR is demonstrated which can be attenuated by pre-training administration of caffeine, and the present findings indicate that the spatiallearning deficit inSHR is not directly related to hypertension.
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