Osthole Promotes Endochondral Ossification and Accelerates Fracture Healing in Mice

@inproceedings{Zhang2016OstholePE,
  title={Osthole Promotes Endochondral Ossification and Accelerates Fracture Healing in Mice},
  author={Zhongrong Zhang and Wing Nang Leung and Gang Li and Yau Ming Lai and Chun Wai CW Chan},
  booktitle={Calcified Tissue International},
  year={2016}
}
Osthole has been found to restore bone mass in preclinical osteoporotic models. In the present study, we investigated the effects of osthole on bone fracture repair in mice. Adult C57BL/6 mice were subjected to transverse femoral fractures and administrated orally with 20 mg/kg osthole and vehicle solvent daily from week 1 post-operation. Fracture callus were analyzed by plain radiography, micro-computed tomography, histology, molecular imaging and immunohistochemistry and tartrate-resistant… CONTINUE READING
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