Osteostat/tumor necrosis factor superfamily 18 inhibits osteoclastogenesis and is selectively expressed by vascular endothelial cells.

@article{Nardelli2006OsteostattumorNF,
  title={Osteostat/tumor necrosis factor superfamily 18 inhibits osteoclastogenesis and is selectively expressed by vascular endothelial cells.},
  author={Bernardetta Nardelli and Liubov Zaritskaya and William McAuliffe and Yansong Ni and Clint Lincoln and Yun Hee Cho and Charles E. Birse and Wendy Halpern and Stephen E. Ullrich and Paul A. Moore},
  journal={Endocrinology},
  year={2006},
  volume={147 1},
  pages={70-8}
}
Vascular endothelial cells (EC) participate in the process of bone formation through the production of factors regulating osteoclast differentiation and function. In this study, we report the selective expression in primary human microvascular EC of Osteostat/TNF superfamily 18, a ligand of the TNF superfamily. Osteostat protein is detectable in human microvascular EC and is highly up-regulated by IFN-alpha and IFN-beta. Moreover, an anti-Osteostat antibody strongly binds to the vascular… CONTINUE READING
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