Osteoradionecrosis of mandible bone in patients with oral cancer—associated factors and treatment outcomes

@article{Chen2016OsteoradionecrosisOM,
  title={Osteoradionecrosis of mandible bone in patients with oral cancer—associated factors and treatment outcomes},
  author={Jyun An Chen and Chen-Chi Wang and Y K Wong and Ching‐Ping Wang and Rong-San Jiang and Jin-Ching Lin and Chien-Chih Chen and Shih-An Liu},
  journal={Head \& Neck},
  year={2016},
  volume={38}
}
The purpose of this study was to investigate factors associated with osteoradionecrosis (ORN) of the mandible bone in a large cohort of patients with oral cancer. 
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Predictive factors for osteoradionecrosis of the jaws: A retrospective study
TLDR
Osteoradionecrosis of the jaw (ORNJ) is a well‐recognized complication of radiotherapy and predictive factors for the development of ORNJ are assessed.
Identification of predisposing factors for osteonecrosis of the jaw after marginal mandibulectomy in the surgical management of oral squamous cell carcinoma
TLDR
The aim of this study is to evaluate osteonecrosis of the jaw (ONJ) with the extent of marginal mandibulectomy with the help of X-ray diffraction analysis.
A nomogram to predict osteoradionecrosis in oral cancer after marginal mandibulectomy and radiotherapy
TLDR
Investigation of risk factors, including different modalities of radiotherapy, for developing mandibular ORN in patients undergoing marginal mandibulectomy and postoperative radiotherapy finds no useful tool to clinically predict the occurrence of osteoradionecrosis of the mandible quantitatively.
Osteoradionecrosis: Exposing the Evidence Not the Bone.
Clinical study of treatment methods and associated factors in mandibular osteoradionecrosis.
TLDR
The cure rate among patients who received nonoperative and surgical treatment was higher than that observed with nonoperative treatment alone and the treatment method was associated with cure in both univariate and multivariate analyses.
Osteoradionecrosis in a Patient Submitted to Head and Neck Radiotherapy: A Case Report
TLDR
This study reports a case of ORN in the left mandibular body which resulted in a pathological fracture and the patient died before control of ORn was achieved due to a heart attack.
Radiation Therapy and Mandibular Osteoradionecrosis: State of the Art
TLDR
An update on literature data related to mandibular osteoradionecrosis secondary to the irradiation of the head and neck region is provided to guide a clear proposal for clinical measures in the individual MORN situations.
Influence of bisphosphonates on clinical features of osteoradionecrosis of the maxilla and mandible.
TLDR
Bisphosphonate use appears to contribute to earlier development of Osteoradionecrosis in patients treated with combined radiation and bisph phosphate therapy, and long-term prospective studies are needed to understand the pathogenesis of ORN.
Frequency of osteoradionecrosis of the lower jaw after radiotherapy of oral cancer patients correlated with dosimetric parameters and other risk factors
TLDR
The results of this retrospective study reveal that oral cavity cancer patients who underwent pre-RT dental surgery as well as dosimetric parameters using Dmax, higher mean doses and more than 40% PTV intersection with the lower jaw bone are independent risk factors for ORN.
Regarding A Nomogram to Predict Osteoradionecrosis in Oral Cancer After Marginal Mandibulectomy and Radiotherapy.
TLDR
There is no useful tool to clinically predict the occurrence of osteoradionecrosis of the mandible quantitatively and surgeons should be more discrete regarding the treatment plan for patients with higher probability of ORN.
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References

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TLDR
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TLDR
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