Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis.

@article{Romas2002OsteoprotegerinRO,
  title={Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis.},
  author={Evange Romas and Natalie A Sims and Daphne K. Hards and Mandy Lindsay and Julian M. W. Quinn and Peter F. J. Ryan and Colin Robert Dunstan and Thomas J Martin and Matthew T. Gillespie},
  journal={The American journal of pathology},
  year={2002},
  volume={161 4},
  pages={1419-27}
}
Rheumatoid arthritis is characterized by progressive synovial inflammation and joint destruction. While matrix metalloproteinases (MMPs) are implicated in the erosion of unmineralized cartilage, bone destruction involves osteoclasts, the specialized cells that resorb calcified bone matrix. RANK ligand (RANKL) expressed by stromal cells and T cells, and its cognate receptor, RANK, were identified as a critical ligand-receptor pair for osteoclast differentiation and survival. A decoy receptor for… CONTINUE READING
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