Osteoprotegerin induces morphological and functional alterations in mouse pancreatic islets.

@article{Toffoli2011OsteoprotegerinIM,
  title={Osteoprotegerin induces morphological and functional alterations in mouse pancreatic islets.},
  author={Barbara Toffoli and Stella Bernardi and Riccardo Candido and Nicoletta Sabato and Renzo Carretta and Federica Corallini and Paola Secchiero and Giorgio Zauli and Bruno Fabris},
  journal={Molecular and cellular endocrinology},
  year={2011},
  volume={331 1},
  pages={136-42}
}
Although serum osteoprotegerin (OPG) is significantly increased in diabetic subjects, its potential role in beta cell dysfunction has not been investigated. This study aimed to assess the effect of full-length OPG administered in vivo in mice on pancreatic islet structure and function and its interaction with the renin-angiotensin system (RAS). OPG-treated mice showed increased islet monocyte/macrophage infiltration, fibrosis and apoptosis with reduction of islet function. The remodeling of… CONTINUE READING

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