Osteoprotegerin induces cytoskeletal reorganization and activates FAK, Src, and ERK signaling in endothelial cells.

@article{KobayashiSakamoto2010OsteoprotegerinIC,
  title={Osteoprotegerin induces cytoskeletal reorganization and activates FAK, Src, and ERK signaling in endothelial cells.},
  author={Michiyo Kobayashi-Sakamoto and Emiko Isogai and Ingunn Holen},
  journal={European journal of haematology},
  year={2010},
  volume={85 1},
  pages={26-35}
}
Osteoprotegerin (OPG) is a soluble tumor necrosis factor receptor family member that is expressed by a range of cell types in bone as well as in the vasculature. However, the specific role of OPG in the vascular system is unclear. We recently reported that OPG treatment protects endothelial cells from detachment and apoptotic cell death induced by cysteine proteases of Porphyromonas gingivalis, an important pathogen of adult periodontitis. We also found that OPG activates the extracellular… CONTINUE READING
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