Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis

Abstract

Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor (TNF) receptor superfamily that has been well characterized as a negative regulator of bone remodeling. OPG is also expressed in human breast cancer tissues and cell lines. In vitro studies suggest that OPG exerts tumor-promoting effects by binding to TNF-related apoptosis inducing… (More)
DOI: 10.1002/cam4.277

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