Osteoprotegerin as a marker of cardiovascular risk in children and adolescents with type 1 diabetes

  title={Osteoprotegerin as a marker of cardiovascular risk in children and adolescents with type 1 diabetes},
  author={Ons Fekih and Hamdi Triki and Sonia Triki and Fadoua Neffati and Slaheddine Chouchane and Mohamed Neji Guédiche and Mohamed Fadhel Najjar},
  journal={Pediatric Diabetes},
Elevated osteoprotegerin (OPG) levels have been reported in patients with diabetes complications. We investigated whether plasma OPG levels can be used as a marker of cardiovascular risk in children and adolescents with type 1 diabetes (T1D). 
Increased Circulating Osteoprotegerin Levels in Type 1 Diabetes Mellitus: A Systematic Review and Meta-analysis Based on Observational Studies
The current evidence suggested that circulating OPG Levels are significantly higher in T1D than in healthy controls, and the increase of OPG levels are influenced by factors of race and HbA1c.
Effects of Salt Loading on Plasma Osteoprotegerin Levels and Protective Role of Potassium Supplement in Normotensive Subjects.
Salt loading can enhance the production of circulating OPG and potassium supplementation can reverse the effects of excessive OPG, which may improve the understanding of the roles of salt and potassium in the risk of cardiovascular disorders.
Predictive ability of circulating osteoprotegerin as a novel biomarker for early detection of acute kidney injury induced by sepsis
This study revealed a significant elevation of circulating OPG in septic patients with different levels of severity and those who progressed to AKI, and showed a significant correlation to KIM-1 and cystatin, as well as conventional renal, inflammatory, and endothelial markers.
Can Brain Natriuretic Peptides and Osteoprotegerin Serve As Biochemical Markers for the Detection of Aortic Pathology in Children and Adolescents with Turner Syndrome?
Further meticulous longitudinal studies are required before BNP, NT pro-BNP, and OPG are used as vascular biomarkers for the detection of aortic disease in childhood and adolescent TS.
Acute Hyperinsulinemia Alters Bone Turnover in Women and Men With Type 1 Diabetes
Exogenous hyperinsulinemia acutely alters bone turnover, suggesting a need to determine whether strategies to promote healthy remodeling may protect bone quality in T1D and why SCL was the only BTM that changed differently in women than men.
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Circulating osteoprotegerin is correlated with lipid profile, insulin sensitivity, adiponectin and sex steroids in an ageing male population
The purpose of this study was to look at the correlates of OPG in an elderly male population and found no significant differences between the sexes.
Osteoprotegerin is associated with cardiovascular risk in hypertension and/or diabetes
Eur J Clin Invest 2012; 42 (5): 548–556
Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications
Although the clinical prognostic use of OPG may seem far away, OPG does look promising as a biomarker in order to help the cardiologist to a better risk-stratification of the patients.
Osteoprotegerin serum levels in children with type 1 diabetes: a potential modulating role in bone status.
OPG could be a new marker of reduced bone mass in children with type 1 (insulin-dependent) diabetes mellitus and have a significant increase of OPG levels, which are correlated to calcaneal BUA and HbA1c values.
Osteoprotegerin as a Marker of Atherosclerosis in Diabetic Patients
The aim of this review study was to investigate the relationship between plasma OPG/RANKL levels and endothelial dysfunction as assessed using noninvasive methods, in the general population and in diabetic patients to identify a means of predicting, via nonin invasive methods, later development of endothelium dysfunction and vascular complications in diabetes patients.
Osteoprotegerin Is an Independent Predictor of Vascular Events in Finnish Adults With Type 1 Diabetes
Serum OPG is an independent predictor of CV complications and may be directly involved in extraosseous calcification, resulting in stiffening of the arteries and subsequent vascular insufficiency in patients with T1D.
Plasma osteoprotegerin levels predict cardiovascular and all-cause mortality and deterioration of kidney function in type 1 diabetic patients with nephropathy
High levels of osteoprotegerin predict all-cause and cardiovascular mortality in patients with diabetic nephropathy and deterioration of kidney function towards end-stage renal disease.
Increased plasma concentrations of osteoprotegerin in type 2 diabetic patients with microvascular complications.
Increased levels of OPG in plasma from diabetic patients with microvascular complications and glycemic control in patients with type 2 diabetes indicates that OPG may be involved in the development of vascular dysfunction in diabetes.