Osteoprotegerin and rank ligand expression in prostate cancer.

@article{Brown2001OsteoprotegerinAR,
  title={Osteoprotegerin and rank ligand expression in prostate cancer.},
  author={J. Michael Brown and Eva Corey and Zsung Dao Lee and Lawrence D. True and Theodore J. Yun and Mehrdad M Tondravi and Robert L. Vessella},
  journal={Urology},
  year={2001},
  volume={57 4},
  pages={
          611-6
        }
}
OBJECTIVES To investigate the expression of osteoprotegerin (OPG) and RANK ligand (RANKL) in human prostatic tissues. The factors regulating the increased turnover associated with prostate cancer (CaP) bone metastasis are unknown. OPG and RANKL are recently identified regulators of bone resorption and bone remodeling. METHODS Tissues from 28 patients with CaP and from 4 normal organ donors were analyzed by reverse transcriptase-polymerase chain reaction and immunohistochemistry for the… CONTINUE READING
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