Osteoprotegerin (OPG) Expression by Breast Cancer Cells in vitro and Breast Tumours in vivo – A Role in Tumour Cell Survival?

  title={Osteoprotegerin (OPG) Expression by Breast Cancer Cells in vitro and Breast Tumours in vivo – A Role in Tumour Cell Survival?},
  author={Ingunn Holen and Simon S. Cross and Helen L. Neville-Webbe and Neil Alan Cross and Sabapathy Prakash Balasubramanian and Peter Ian Croucher and C. Alyson Evans and Jennifer M. Lippitt and Robert Coleman and Colby L. Eaton},
  journal={Breast Cancer Research and Treatment},
In addition to its role in bone turnover, osteoprotegerin (OPG) has been reported to bind to and inhibit Tumour necrosis factor-related apoptosis inducing ligand (TRAIL). TRAIL is produced in tumours by invading monocytes, inducing apoptosis in neoplastic cells sensitive to this cytokine. OPG production by tumour cells would therefore be a novel mechanism whereby cancer cells evade host defences and gain a growth advantage. In this study we show that OPG produced by breast cancer cells enhances… CONTINUE READING
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