Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function.

@article{Yun2001OsteoprotegerinAC,
  title={Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function.},
  author={Theodore J. Yun and Michelle D. Tallquist and Alexandra Aicher and Katherine L. Rafferty and Aaron J Marshall and James J Moon and M E Ewings and Mariette Mohaupt and Susan W. Herring and Edward A. Clark},
  journal={Journal of immunology},
  year={2001},
  volume={166 3},
  pages={1482-91}
}
Osteoprotegerin (OPG) is a CD40-regulated gene in B cells and dendritic cells (DCs). We investigated the role of OPG in the immune system by generating opg(-/-) mice. Like its role as a regulator of bone metabolism, OPG also influences processes in the immune system, notably in B cell development. Ex vivo, opg(-/-) pro-B cells have enhanced proliferation to IL-7, and in opg(-/-) spleen, there is an accumulation of type 1 transitional B cells. Furthermore, opg(-/-) bone marrow-derived DCs are… CONTINUE READING