Osteoprogenitor cells and osteoblasts are targets for hepatitis C virus.

  title={Osteoprogenitor cells and osteoblasts are targets for hepatitis C virus.},
  author={Rainer Kluger and Helmut M{\"u}hlberger and Oskar Hoffmann and Christian Ernst Berger and Alfred von Engel and Borislava G. Pavlova},
  journal={Clinical orthopaedics and related research},
The goal of this study was to determine whether human osteoblasts might harbor the hepatitis C virus. We tested for positive-strand and negative-strand (replicative) hepatitis C virus RNA by reverse transcriptase-polymerase chain reaction, by in situ reverse transcriptase-polymerase chain reaction for intracellular localization of the hepatitis C virus, and by amplicon sequencing in in vitro differentiated mature osteoblasts from STRO-1+ osteoprogenitor cells from patients with chronic… CONTINUE READING


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