Osteoporotic fracture models.

  title={Osteoporotic fracture models.},
  author={A. Hamish R. W. Simpson and Iain R. Murray},
  journal={Current osteoporosis reports},
  volume={13 1},
Animal models are widely used to investigate the pathogenesis of osteoporosis and for the clinical testing of anti-resorptive drugs. However, osteoporotic fracture models designed to investigate novel ways to treat fractures of osteoporotic bone must fulfil requirements distinct from those of pharmacological testing. Bone strength and toughness, implant fixation and osteointegration and fracture repair are of particular interest. Osteoporotic models should reflect the underlying clinical… CONTINUE READING

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