Osteoporosis associated with rheumatoid arthritis: pathogenesis and management.

  title={Osteoporosis associated with rheumatoid arthritis: pathogenesis and management.},
  author={Ian I. Joffe and Sol Epstein},
  journal={Seminars in arthritis and rheumatism},
  volume={20 4},
Rheumatoid arthritis is associated with both localized and generalized osteoporosis. Localized osteoporosis can be considered to be caused by local disease mechanisms, including the generation of factors from activation of the cytokine pathway. The etiology of generalized osteoporosis has been difficult to elucidate, particularly because of the lack of sensitive techniques to measure bone mineral density. The introduction of single- and dual-photon absorptiometry and quantitative computed… CONTINUE READING


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