Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis.

  title={Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis.},
  author={Zhiyong Mi and Syamal Dave Bhattacharya and Victoria M. Kim and Hongtao Guo and Lindsay Jones Talbot and P. C. Kuo},
  volume={32 4},
The interaction between cancer and its local microenvironment can determine properties of growth and metastasis. A critical component of the tumor microenvironment in this context is the cancer-associated fibroblast (CAF), which can promote tumor growth, angiogenesis and metastasis. It has been hypothesized that CAF may be derived from mesenchymal stromal cells (MSC), derived from local or distant sources. However, the signaling mechanisms by which tumors and MSCs interact to promote CAF… CONTINUE READING
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