Osteopontin promoter polymorphisms at locus -443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma.

@article{Dong2013OsteopontinPP,
  title={Osteopontin promoter polymorphisms at locus -443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma.},
  author={Qiongzhu Dong and Xiaofei Zhang and Yue Zhao and Hu-Liang Jia and Hai-jun Zhou and Chun Yan Dai and Hai-Jing Sun and Yi Qin and Wei-De Zhang and Ning Ren and Qing-hai Ye and Lun-xiu Qin},
  journal={Hepatology},
  year={2013},
  volume={57 3},
  pages={1024-34}
}
UNLABELLED Osteopontin (OPN) plays a crucial role in hepatocellular carcinoma (HCC) metastasis. However, little is known about the impact of OPN polymorphisms on cancer progression. In this study, we first identified the single nucleotide polymorphisms (SNPs) in the OPN promoter region by direct sequencing in 30 HCCs, and then evaluated the prognostic values of the selected ones in two large cohorts of 826 HCC patients. The identified SNPs were functionally analyzed using in vitro and in vivo… CONTINUE READING
22 Extracted Citations
35 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 22 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 35 references

Similar Papers

Loading similar papers…