Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival.

@article{Hsu2010OsteopontinpositiveIT,
  title={Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival.},
  author={Hui-Ping Hsu and Y O Shan and M D Lai and P. A. Lin},
  journal={Cancer biology & therapy},
  year={2010},
  volume={10 2},
  pages={144-54}
}
PURPOSE Tumor-associated macrophages (TAMs) promote cancer cell proliferation and distant metastases. Osteopontin (OPN) is overexpressed in several human cancer cells and in TAMs. Therefore, we set out to determine the role of OPN-expressing macrophages in cancer. RESULTS In 100 ampullary cancers, diffuse cytoplasmic positivity for OPN was found in infiltrating TAMs in 36 patients and marginal TAMs in 32 patients; OPN(+) macrophages were absent in 32 patients. Expression patterns of OPN in… CONTINUE READING
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