Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice.

@article{Coombes2015OsteopontinNA,
  title={Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice.},
  author={Jason D. Coombes and Marzena Swiderska-syn and Laurent Doll{\'e} and Danielle T Reid and Bertus Eksteen and Lee C Claridge and Marco Antonio Briones-Orta and Shishir Shetty and Ye Htun Oo and Antonio Riva and Shilpa Chokshi and Salvatore Papa and Zhiyong Mi and P. C. Kuo and R. Sanders Williams and Ali Canbay and David H Adams and Anna Mae Diehl and Leo A van Grunsven and Steve Choi and Wing-Kin Syn},
  journal={Gut},
  year={2015},
  volume={64 7},
  pages={1120-31}
}
BACKGROUND Chronic liver injury triggers a progenitor cell repair response, and liver fibrosis occurs when repair becomes deregulated. Previously, we reported that reactivation of the hedgehog pathway promotes fibrogenic liver repair. Osteopontin (OPN) is a hedgehog-target, and a cytokine that is highly upregulated in fibrotic tissues, and regulates stem-cell fate. Thus, we hypothesised that OPN may modulate liver progenitor cell response, and thereby, modulate fibrotic outcomes. We further… CONTINUE READING
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