Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin.

@article{Lund2013OsteopontinMM,
  title={Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin.},
  author={Susan Amanda Lund and Carole L. Wilson and Elaine W. Raines and Jingjing Tang and Cecilia M. Giachelli and Marta Scatena},
  journal={Journal of cellular biochemistry},
  year={2013},
  volume={114 5},
  pages={1194-202}
}
Osteopontin (OPN) is highly expressed by macrophages and plays a key role in the pathology of several chronic inflammatory diseases including atherosclerosis and the foreign body reaction. However, the molecular mechanism behind OPN regulation of macrophage functions is not well understood. OPN is a secreted molecule and interacts with several integrins via two domains: the RGD sequence binding to α(v) -containing integrins, and the SLAYGLR sequence binding to α(4) β(1), α(4) β(7), and α(9) β(1… CONTINUE READING

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