Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells

@article{Tajima2010OsteopontinmediatedEH,
  title={Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells},
  author={Kenichirou Tajima and Rina Ohashi and Yoshitaka S Sekido and Toyoaki Hida and Takeshi Nara and Mizuo Hashimoto and Shinichiro Iwakami and Kunihiko Minakata and Toshifumi Yae and Fumiyuki Takahashi and Hideyuki Saya and Kazuo Takahashi},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={1941-1951}
}
Malignant pleural mesothelioma (MPM) is resistant to chemotherapy and thus shows a dismal prognosis. Osteopontin (OPN), a secreted noncollagenous and phosphoprotein, is suggested to be involved in the pathogenesis of MPM. However, the precise role of OPN, especially in the multidrug resistance of MPM, remains to be elucidated. We therefore established stable transfectants (ACC-MESO-1/OPN), which constitutively express OPN, to determine its role in the chemoresistance observed in MPM. The… CONTINUE READING
19 Citations
41 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…