Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.

@article{Guarino2005OsteopontinIO,
  title={Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.},
  author={Valentina Guarino and Pinuccia Faviana and Giuliana Salvatore and Maria Domenica Castellone and Anna Maria Cirafici and Valentina De Falco and Angela Celetti and Riccardo Giannini and Fulvio Basolo and Rosa Marina Melillo and Massimo Santoro},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 9},
  pages={
          5270-8
        }
}
UNLABELLED The transmembrane glycoprotein CD44v6 is overexpressed in most papillary thyroid carcinomas (PTC). We previously reported that osteopontin (OPN), a secreted glycoprotein that functions as a ligand for CD44v6, is overexpressed in thyrocytes transformed by the RET/PTC oncogene. OBJECTIVE In this study we asked whether OPN is overexpressed in human PTC samples, and whether its expression correlates with clinical and histological features of the tumors. Furthermore, we wanted to… CONTINUE READING

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