Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function.

@article{Zeyda2011OsteopontinIA,
  title={Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function.},
  author={Maximilian Zeyda and Karina Gollinger and Jelena Todoric and F. W. Kiefer and Maike Keck and Oskar Aszmann and Gerhard Prager and Gerhard J Zlabinger and Peter Petzelbauer and Thomas Michael Stulnig},
  journal={Endocrinology},
  year={2011},
  volume={152 6},
  pages={
          2219-27
        }
}
Osteopontin (OPN) is highly up-regulated in adipose tissue in human and murine obesity and has been recently shown to be functionally involved in the pathogenesis of obesity-induced adipose tissue inflammation and associated insulin resistance in mice. OPN is a protein with multiple functions and acts as a chemokine and an inflammatory cytokine through a variety of different receptors (CD44, integrins). It is expressed in many cell types including adipose tissue macrophages (ATM). However, the… CONTINUE READING
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