Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification.

@article{Steitz2002OsteopontinIM,
  title={Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification.},
  author={Susan A Steitz and Mei Y. Speer and Marc D McKee and Lucy Liaw and Manuela Guedes de Almeida and Hsueh An Yang and Cecilia M. Giachelli},
  journal={The American journal of pathology},
  year={2002},
  volume={161 6},
  pages={
          2035-46
        }
}
Ectopic calcification, the abnormal calcification of soft tissues, can have severe clinical consequences especially when localized to vital organs such as heart valves, arteries, and kidneys. Recent observations suggest that ectopic calcification, like bone biomineralization, is an actively regulated process. These observations have led a search for molecular determinants of ectopic calcification. A candidate molecule is osteopontin (OPN), a secreted phosphoprotein invariantly associated with… CONTINUE READING
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