Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.

@article{Cook2006OsteopontinIO,
  title={Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.},
  author={Amy C. Cook and Ann F. Chambers and Eva Ann Turley and Alan B. Tuck},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 34},
  pages={24381-9}
}
Osteopontin (OPN) is a tumor-associated, secreted phosphoprotein that has been implicated in breast cancer progression and metastasis. Research concerning how OPN functions in tumor progression has led to the identification of a limited number of genes that contribute functionally to OPN-induced cellular behaviors. Recent microarray analysis, comparing 21NT breast cancer cells transfected to constitutively overexpress OPN with control cells, revealed hyaluronan synthase 2 (HAS2) to be a gene… CONTINUE READING

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