Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.

  title={Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.},
  author={Amy C. Cook and Ann F. Chambers and Eva Ann Turley and Alan B. Tuck},
  journal={The Journal of biological chemistry},
  volume={281 34},
Osteopontin (OPN) is a tumor-associated, secreted phosphoprotein that has been implicated in breast cancer progression and metastasis. Research concerning how OPN functions in tumor progression has led to the identification of a limited number of genes that contribute functionally to OPN-induced cellular behaviors. Recent microarray analysis, comparing 21NT breast cancer cells transfected to constitutively overexpress OPN with control cells, revealed hyaluronan synthase 2 (HAS2) to be a gene… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 27 extracted citations


Publications referenced by this paper.
Showing 1-2 of 2 references

Bone Metastasis: Experimental and Clinical Therapeutics (Rabbani

  • A. L. Allan, A. B. Tuck, V.H.C. Bramwell, T. A. Vandenberg, E. W. Winquist, A. F. Chambers
  • G. S. a. S.,
  • 2005

OPN Induces HAS2 Expression in Breast Cancer Cells

  • S. Mohapatra, X. Yang, J. A. Wright, E. A. Turley, A. H. Greenberg
  • J. Exp. Med
  • 1996

Similar Papers

Loading similar papers…