Osteopontin induces angiogenesis of murine neuroblastoma cells in mice.

  title={Osteopontin induces angiogenesis of murine neuroblastoma cells in mice.},
  author={Fumiyuki Takahashi and Shigeru Akutagawa and Hisao Fukumoto and Shoji Tsukiyama and Yuichiro Ohe and Kazuhisa Takahashi and Yoshinosuke Fukuchi and Nagahiro George Saijo and Kazuto Nishio},
  journal={International journal of cancer},
  volume={98 5},
Angiogenesis is an essential process for tumor growth and is regulated by tumor-derived angiogenic cytokines. Osteopontin (OPN) is one of the cytokines produced by various tumor cells and is suggested to be involved in angiogenesis by upregulating endothelial cell migration in cooperation with vascular endothelial cell growth factor (VEGF). To provide evidence of OPN involvement in a causal role in tumor angiogenesis, we generated a stable transfectant from murine neuroblastoma C1300 cells to… CONTINUE READING


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