Osteopontin-induced brown adipogenesis from white preadipocytes through a PI3K-AKT dependent signaling.

@article{Zhong2015OsteopontininducedBA,
  title={Osteopontin-induced brown adipogenesis from white preadipocytes through a PI3K-AKT dependent signaling.},
  author={Xiao-Juan Zhong and Xiao-Dan Shen and J Wen and Ying Kong and Jia-Jia Chu and Guo-Qiang Yan and Teng Li and Dan Liu and Meng-Qing Wu and Guohua Zeng and Ming He and Qi-ren Huang},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={459 3},
  pages={553-9}
}
Recent studies have shown that OPN (osteopontin) plays critical roles in cell survival, differentiation, bio-mineralization, cancer and cardiovascular remodeling. However, its roles in the differentiation of brown adipocytes and the underlying mechanisms remain unclear. Therefore, the aim of this study was to investigate the roles of OPN in the brown adipogenesis and the underlying mechanisms. It was shown that the OPN successfully induced the differentiation of 3T3-L1 white preadipocytes into… CONTINUE READING
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