Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets

@article{Xanthou2007OsteopontinHA,
  title={Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets},
  author={Georgina Xanthou and Themis Alissafi and Maria Semitekolou and Davina C M Simoes and Erasmia Economidou and Mina Gaga and Bart M. Lambrecht and Clare M Lloyd and Vily Panoutsakopoulou},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={570-578}
}
Osteopontin (Opn) is important for T helper type 1 (TH1) immunity and autoimmunity. However, the role of this cytokine in TH2-mediated allergic disease as well as its effects on primary versus secondary antigenic encounters remain unclear. Here we demonstrate that OPN is expressed in the lungs of asthmatic individuals and that Opn-s, the secreted form of Opn, exerts opposing effects on mouse TH2 effector responses and subsequent allergic airway disease: pro-inflammatory at primary systemic… CONTINUE READING
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