Osteopontin function in pathology: lessons from osteopontin-deficient mice.

  title={Osteopontin function in pathology: lessons from osteopontin-deficient mice.},
  author={S R Rittling and David T. Denhardt},
  journal={Experimental nephrology},
  volume={7 2},
Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to several different integrins. While numerous activities have been ascribed to OPN in vitro, and several in vivo functions have been suggested for the molecule, including much attention focused recently on OPN in different pathologies, the actual role that the protein plays in mammalian physiology remains conjectural. Analysis of recently developed strains of mice lacking OPN because of a targeted disruption… CONTINUE READING

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