Osteopontin expression of circulating T cells and plasma osteopontin levels are increased in relation to severity of heart failure.

@article{Soejima2007OsteopontinEO,
  title={Osteopontin expression of circulating T cells and plasma osteopontin levels are increased in relation to severity of heart failure.},
  author={Hirofumi Soejima and Atsushi Irie and Takashi Fukunaga and Yoko Oe and Shinobu Kojima and Koichi Kaikita and Hiroaki Kawano and Seigo Sugiyama and Michihiro Yoshimura and Hideki Kishikawa and Yasuharu Nishimura and Hisao Ogawa},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2007},
  volume={71 12},
  pages={1879-84}
}
BACKGROUND T cells in peripheral blood reflect the systemic inflammatory response in patients with heart failure (HF). In a rat model of HF, osteopontin is dramatically increased in the left ventricular myocardium, so the association between osteopontin and HF was examined in the present study. METHODS AND RESULTS Peripheral blood was collected from 93 patients with heart disease and 38 controls. Left ventricular ejection fraction (LVEF) was calculated using a modified Simpson's rule. The 93… CONTINUE READING
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